Specific HDAC6 inhibition by ACY-738 reduces SLE pathogenesis in NZB/W mice
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چکیده
منابع مشابه
Class I and II histone deacetylase inhibition by ITF2357 reduces SLE pathogenesis in vivo.
We sought to determine if a specific class I and II HDAC inhibitor (ITF2357) was able to decrease disease in lupus-prone NZB/W mice through regulation of T cell profiles. From 22 to 38 weeks-of-age, NZB/W and non-lupus NZW mice were treated with ITF2357 (5 mg/kg or 10 mg/kg), or vehicle control. Body weight and proteinuria were measured every 2 weeks, while sera anti-dsDNA and cytokine levels w...
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ژورنال
عنوان ژورنال: Clinical Immunology
سال: 2016
ISSN: 1521-6616
DOI: 10.1016/j.clim.2015.11.007